The Institute for Advanced Radiation Oncology

Treatment Technology

Brachytherapy:
Advancing a New Dimension in Radiation Implant Treatment

Monmouth Medical Center continues to be the region’s leader in offering internal radiation therapy, which involves the placement of the radioactive substance directly in or in close proximity to the cancer site.

Monmouth's prominence in brachytherapy — a specialized form of internal radiation therapy — took root in 1998 when Monmouth introduced two advanced radiation implant therapies for the treatment of prostate cancer — high-dose rate (HDR) brachytherapy for intermediate or advanced-stage disease and low-dose rate (LDR) permanent seed brachytherapy for early cancers.

How Internal Radiation Therapy Works
Internal radiation therapy places the source of the high-energy rays as close as possible to the cancer cells so that fewer normal cells are exposed to radiation. Additionally, a higher total dose of radiation can be delivered in a shorter time, compared to external treatment.

Instead of using a large radiation machine, the radioactive material is placed directly into — or as close as possible to — the affected area. Some of the radioactive substances used for internal radiation treatment include cesium, iridium, iodine, phosphorus and palladium.

While implant radiation means internal radiation treatment, it also is referred to in other terms, including interstitial radiation, intracavitary radiation or brachytherapy. Each is a different form of internal radiation therapy:

  • In brachytherapy, the radioactive source, which is sealed in a small container, is placed on the surface of the body near the tumor or a short distance from the affected area.
  • Interstitial radiation involves the placement of the radiation source directly in the affected tissue, usually in small tubes or containers. These implants may be temporary or permanent.
  • When intracavitary radiation is used, a container of radioactive material is placed in a cavity of the body such as the uterus.
  • Internal radiation also may be given by injecting a solution of radioactive substance into the bloodstream or a body cavity. When the substance is injected, it is not sealed in a container and may be called unsealed internal radiation therapy.

Internal radiation therapy often is used for cancers of the prostate, breast, head and neck, uterus, thyroid, cervix. It also can be combined with external radiation therapy, including IMRT, IGRT, neuroradiosurgery and TomoTherapy and chemotherapy.

How Brachytherapy Works
There are two types of brachtherapy:

-- High-dose rate (HDR) brachytherapy is used for the treatment of advanced prostate cancer, as well as for certain types of breast, gynecologic, lung, head and neck and extremity cancers.

The technique involves implanting radioactive sources through a computed-guided minimally invasive technique into a confined area. These temporary catheters emit high doses of radiation that destroy the cancer cells, sparing normal surrounding tissues. The implants are immediately removed after each treatment session.

Several years ago, HDR brachytherapy reached a new level of precision and sophistication with implementation of real-time, dynamic computer-assisted planning technology.

Mammosite technology — another form of HDR brachytherapy offered at Monmouth — is benefiting certain breast cancer patients by reducing treatment time by about five weeks. Some lung and head and neck cancer patients are treated using this type of approach.

-- Low-dose rate (permanent seed) brachytherapy involves the placement of low-energy radiation seeds— in contrast to HDR brachytherapy. The treatment has shown much success in the treatment of early stage prostate cancer.

Additional information on internal radiation therapy, including the various forms of brachytherapy, is available from the National Cancer Institute, National Comprehensive Cancer Network and American Cancer Society.

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