Clinical Research

Clinical Trial Programs

Brain

CENTRIC
Cilengitide in subjects with newly diagnosed GBM and methylated MGMT gene promoter-a Multicenter, open-label, controlled Phase III study, testing cilengitide in combination with standard treatment (Temozolomide with concomitant radiation therapy, followed by Temozolomide maintenance therapy) versus standard treatment alone

MMC
Evaluation of the Use of Adaptive Fractionated Stereotactic Radiosurgery for Spinal and Paraspinal Tumors Using Image Guided Tomotherapy

RTOG 0825
Phase III Double Blind Placebo-Controlled Trial of Conventional Chemoradiation and Adjuvant Temozolomide Plus Bevacizumab Vs. Conventional Concurrent Chemoradiation and Adjuvant Temozolomide in Patients with Newly Diagnosed Glioblastoma

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Breast

Breast ECOG 2504 (TAILORx Trial)
A Phase III Randomized Study of Adjuvant Combination Chemotherapy and Hormonal Therapy vs. Adjuvant Hormonal Therapy Alone in Women with Previously Resected Axillary Node-Negative Breast Cancer with Various Levels of Risk for Recurrence

Breast IBCSG 2402 (Suppression of Ovarian Function Trial/SOFT)
A Phase III Trial Evaluating the Role of Ovarian Function Suppression and the Role of Exemestane Adjuvant Therapies for Premenopausal Women with Endocrine Responsive Breast Cancer

NSABP B44
A Multicenter Phase III randomized Trial of Adjuvant Therapy for Patients with Her-2 Positive, Node Positive or High Risk Node Negative Breast Cancer Comparing Chemotherapy Plus Trastuzumab with Chemotherapy Plus Trastuzumab Plus Bevacizumab (BETH)

AVF 4349n
An observational study of treatment Patterns and Safety Outcomes for Metastatic or Locally Recurrent Breast Cancer (VIRGO)
SUB-STUDY-Archival Tissue Collection in association with Main Study

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Gastrointestinal (GI)

RTOG 0436
A Phase III Trial Evaluating the addition of Cetuximab to Paclitaxel, Cisplatin, and Radiation for Patients with Esophageal Cancer who are Treated without Surgery

RTOG 0822
Phase II Evaluation of Preoperative Chemotherapy Utilizing Intensity Modulated Radiation Therapy (IMRT) in Combination with Capecitabine and Oxaliplatin for Patients with Locally Advanced Rectal Cancer

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Genetourinary (GU)

Prostate MMC
Phase I/II Study to Evaluate Feasibility and Validation of Intensity Modulated Radiation Therapy (IMRT) for Prostate Cancer at High Dose Levels

Renal Cell ECOG E2805
A Randomized Double-Blind Phase III Trial of Adjuvant Sunitinib vs. Sorafenib vs. Placebo in Patients with Resected Renal Cell Carcinoma

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Gynecologic

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Head and Neck

RTOG 0514
Establishment of a Head and Neck Tissue Bank

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Lung

Non-Small Cell Lung Cancer ACOSOG Z4032
A Randomized Phase III Study of Sublobar Resection vs. Sublobar Resection, plus Brachytherapy in High-Risk Patients with Non-Small Cell Lung Cancer 3 cm or Smaller

RTOG 0617
A Randomized Phase III Comparison of Standard- Dose (60 Gy) Versus High-Dose (74 Gy) Conformal Radiotherapy with Concurrent and Consolidation Carboplatin/Paclitaxel in Patients with Stage IIIA/IIIB Non-Small Cell Lung Cancer

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Supportive Oncology

MMC
Study of Stereotactic Body Radiotherapy for Recurrent or Metastatic Lesions to the Lung, Liver, Spine and Viscera

MMC
Phase III Randomized Study of Calendula vs. Biafine to Prevent Radiation-Induced Dermatitis

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