Clinical Research

Clinical Trial Programs

Brain

Gliomas RTOG 0424
A Phase II Study of a Temozolomide-Based Chemoradiotherapy Regimen for High Risk Low-Grade Gliomas

Glioblastoma RTOG 0525
A Phase III Trial Comparing Conventional Adjuvant Temozolomide With Dose-Intensive Temozolomide in Patients with Newly Diagnosed Glioblastoma

[top]


Breast

Diagnostics and Prevention

Breast CTLM
Computed Tomography Laser Mammography (CTLM ®) System Model 1020

Adjuvant

Breast RTOG 0413/NSABP B-39
A Randomized Phase III Study of Conventional Whole Breast Irradiation (WBI) vs. Partial Breast Irradiation (PBI) for Women with Stage 0, I or II Breast Cancer (some limitations as of 12/12/06)

Breast ECOG (TAILORx Trial)
A Phase III Randomized Study of Adjuvant Combination Chemotherapy and Hormonal Therapy vs. Adjuvant Hormonal Therapy Alone in Women with Previously Resected Axillary Node-Negative Breast Cancer with Various Levels of Risk for Recurrence

Breast IBCSG 24-02 (Suppression of Ovarian Function Trial/SOFT)
A Phase III Trial Evaluating the Role of Ovarian Function Suppression and the Role of Exemestane Adjuvant Therapies for Premenopausal Women with Endocrine Responsive Breast Cancer

Metastatic

Breast ABI/CA023 ABI
A Randomized Phase II Trial of Weekly vs. Every Two-Week vs. Every Three-Week Administration of ABI-007 in Combination with Bevacizumab in Women with Metastatic Breast Cancer

Breast SWOG SO226
A Phase III Randomized Trial of Anastrozole vs. Anastrozole and Fulvestrant as First Line Therapy for Post Menopausal Women with Metastatic Breast Cancer

[top]


Gastrointestinal (GI)

Rectal ECOG E5204
A Phase III Study of Postoperative Oxaliplatin, 5-Fluorouracil and Leucovorin vs. Oxaliplatin, 5-Fluorouracil, Leucovorin and Bevacizumab for Stage II or III Rectal Cancer Receiving Pre-Operative Chemoradiation

RTOG 0529
A Phase II Evaluation of Dose-Painted IMRT in Combination with 5-Flurouracil and Mitomycin–C for Reduction of Acute Morbidity in Carcinoma of the Anal Canal


Metastatic

Liver RTOG 0438
A Phase I Trial of Highly Conformal Radiation Therapy for Patients with Liver Metastases
9/12/07 Temporarily Closed

[top]


Genetourinary (GU)

Prostate MMC
Phase I/II Study to Evaluate Feasibility and Validation of Intensity Modulated Radiation Therapy (IMRT) for Prostate Cancer at High Dose Levels

Prostate CALGB 90401
A Phase III Trial Comparing Docetaxel and Prednisone with/without Bevacizumab in Men with Hormone Refractory Prostate Cancer

Renal Cell ECOG E2805
A Randomized Double-Blind Phase III Trial of Adjuvant Sunitinib vs. Sorafenib vs. Placebo in Patients with Resected Renal Cell Carcinoma

[top]


Gynecologic

Ovarian GOG 0218
A Phase III Trial of Carboplatin and Paclitaxel plus Placebo vs. Carboplatin and Paclitaxel, plus Concurrent Bevacizumab (NSC #744865, IND #7921), Followed by Placebo vs. Carboplatin and Paclitaxel, plus Concurrent and Extended Bevacizumab, in Women with Newly Diagnosed, Previously Untreated, Stage III (Suboptimal) and All Stage IV, Epithelial Ovarian or Primary Peritoneal Cancer

RTOG 0418
A Phase II Study of Intensity Modulated Radiation Therapy (IMRT) to the Pelvis +/- Chemotherapy for Post-Operative Patients with either Endometrial or Cervical Carcinoma

[top]


Head and Neck

RTOG 0435
A Randomized Phase III, Double –Blind, Placebo Controlled Study to Evaluate the Efficacy and Safety of Palifermin for the Reduction of Oral Mucositis in Patients with Locally Advanced Head and Neck Cancer Receiving Radiation Therapy with Concurrent Chemotherapy. (Followed by surgery for selected patients)

RTOG 0514
Establishment of a Head and Neck Tissue Bank

[top]



Lung

GSK 109493
A Double-Blind, Randomized, Placebo-Controlled Phase III Study to Assess the Efficacy of recMAGE-A3 + AS15 Antigen-Specific Cancer Immunotherapeutic as Adjuvant Therapy in Patients with Resectable MAGE-A3(+) positive Non-Small Cell Lung Cancer

RTOG 0127/E5597
Phase III Chemoprevention Trial of Selenium Supplementation in Persons with Resected Stage I Non-Small Cell Lung Cancer

Small Cell Lung Cancer RTOG 0212
A Phase I/II Randomized Trial of Two Doses (Phase III-Standard vs. High) and Two Dose High Schedule (Phase II-Once vs. Twice Daily) for Delivering Prophylactic Cranial Irradiation for Patients with Limited Disease Small Cell Lung Cancer

Non-Small Cell Lung Cancer ACOSOG Z4032
A Randomized Phase III Study of Sublobar Resection vs. Sublobar Resection, plus Brachytherapy in High-Risk Patients with Non-Small Cell Lung Cancer 3 cm or Smaller

RTOG 0617
A Randomized Phase III Comparison of Standard- Dose (60 Gy) Versus High-Dose (74 Gy) Conformal Radiotherapy with Concurrent and Consolidation Carboplatin/Paclitaxel in Patients with Stage IIIA/IIIB Non-Small Cell Lung Cancer

[top]


Supportive Oncology

MMC
Study of Stereotactic Body Radiotherapy for Recurrent or Metastatic Lesions to the Lung, Liver, Spine and Viscera

AVF3991N/Registry
An Observational Study of Avastin (Bevacizumab) in Combination with Chemotherapy for Treatment of Metastatic or Locally Advanced and Unresectable Colorectal Cancer, Metastatic or Locally Advanced Non-Small Cell Lung Cancer (excluding Predominant Squamous Cell Histology), Metastatic or Locally Recurrent Breast Cancer

Caphosol® Oral Mucositis Follow-Up Observational Registry Trial
COMFORT
An Open-Label, Multicenter, Uncontrolled Observational Registry in Patients who are Expected to Receive Radiation and/or Chemotherapy that places the Patient at Risk for Developing Oral Mucositis.

MMC
Phase III Randomized Study of Calendula vs. Biafine to Prevent Radiation-Induced Dermatitis

[ top ]

Support the Leon Hess Cancer Center
Careers